Polynucleotides: The Next Generation of Skin Regeneration

Polynucleotides (PDRN/PN) represent one of the most significant advancements in regenerative aesthetic medicine in recent years. Derived from highly purified salmon or trout DNA, these bio-stimulating molecules work by activating the skin’s own repair mechanisms — making them a uniquely biological approach to skin rejuvenation.

What Makes Polynucleotides Different?

Unlike traditional fillers, which add volume, or toxins which relax muscles, polynucleotides work at a cellular level. They stimulate fibroblast activity — the cells responsible for producing collagen and elastin — leading to genuine long-term improvements in skin quality, texture, and hydration.

Polynucleotide therapy is often described as a “biostimulator” — it doesn’t just mask signs of ageing, it actively encourages the skin to regenerate from within.

What Can Polynucleotides Treat?

• Fine lines and wrinkles
• Skin laxity and loss of firmness
• Dull, dehydrated, or uneven skin tone
• Thin, crepey skin around the eyes
• Acne scarring
• Hair loss (alopecia) when injected into the scalp

What to Expect From Treatment

A course of 3–4 sessions spaced 2–4 weeks apart is typically recommended for optimal results. Each session takes approximately 30 minutes. Results build gradually over several weeks as new collagen forms, and continue to improve for up to 3 months after the final treatment.

At Aesthetic Medicine by Dr Numerah, we use only clinically validated polynucleotide products with a proven safety and efficacy record. Contact us today to learn whether PN therapy is right for your skin concerns.